The incident occurred at 12:48 a.m. on the 2100 block of Cummings Highway, the release states.
Sheriff's office traffic investigators were notified and dispatched to the scene "due to the extent of the injuries of the rider," the release reads.
The investigators believe it was a single-vehicle, single-occupant traffic fatality.
"It appears the rider was operating his motorcycle west on Cummings Highway when he lost control of the motorcycle and hit the guard rail," the release states. "The motorcycle continued to slide on the roadway and the rider went under the guard rail and came to rest."
The name of the motorcyclist was not released and no further details were immediately available Saturday evening. The incident remains an active investigation, the release states.
Anyone with information regarding the crash is asked to contact Traffic Homicide Investigator A. Patton at the Hamilton County Sheriff's Office Traffic Division at 423-893-3503, extension 246.